A pair of recent papers from the lab were highlighted for the creative use of DNA metabarcoding to solve problems and ask new questions in fields that span ecology and biomedical science.
1. Our recent paper documenting variation in diet-microbiome linkages in African megafauna was highlighted on the cover of PNAS, Brown University's news, The Division of Biomedicine's 'Kudos' memo, and in the media. This open access paper reflects the results of a long-term collaboration with Rob Pringle from Princeton, Paul Musili from the National Museums of Kenya, a creative honors thesis by Julianna Hsing, and the microbiome-bioinformatics chops of current grad student Bianca Brown.
2. Our recent paper in mSystems creatively translated the DNA metabarcoding approaches that we've been using for wildlife research into a biomedical context to evaluate the plant component of human diets. Using DNA-based evidence of human diet composition could be highly complementary to the current standard of asking human subjects to maintain diet logs in research on human health and nutrition. The paper was highlighted as Editor's pick in the area of Clinical Science and Epidemiology by the journal, as well as in a thoughtful commentary by Frank Maixner, who further highlighted the connections between this work and the fields of archaeology and ancient DNA. The paper was co-led by Aspen Reese based on samples from a prior experimental study investigating the influences of diet interventions on human gut microbiomes, which was led by Lawrence David.
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