The lab has been awarded a Life and Medical Sciences Seed Award from Brown's OVPR for 2024!
This $50,000 award will support improvements in our ability to use DNA barcoding to characterize gastrointestinal nematodes that infect tropical wildlife species. Our own Dr. Ezequiel Vanderhoeven is a world expert in the parasitology of tropical wildlife and the seed award will help us extend our funding base for OneHealth research at the nexus of animal health and ecology. Leveraging expert-verified data to bring wildlife parasitology into the genomics ageWe are on the cusp of a genomics revolution to usher in an era of precision wildlife parasitology—but achieving it requires reforming long-standing traditions in the field. Biologists and health practitioners need to monitor wildlife to ensure effective conservation and identify emerging infectious diseases that may threaten humans and livestock. But we may often misunderstand host-parasite interactions because we rely on overly simplistic methods to study parasite diversity in nature. Fortunately, emerging molecular and bioinformatic techniques can help overcome traditional limitations. We plan to establish genomic workflows to more precisely characterize the diversity and distribution of gastrointestinal parasites that infect wildlife in tropical hotspots. We will accomplish this by constructing and utilizing one of the largest expert-verified databases of helminth DNA in the world. This database will bridge the gap between today’s ‘gold-standard’ practice of using microscopes to painstakingly identify parasites in the field and tomorrow’s need for ‘field-ready’ methods that provide more cost-effective, accurate, and timely parasite identifications—especially for the practitioners who need these data at the right times and places to take action. We will initially use these emerging tools to map hard-to-identify parasites onto wildlife hosts in tropical forests—sloths, monkeys, and tapirs among others—in ways that are more robust than standard techniques could provide. This exciting venture features interdisciplinary collaboration among veterinarians, parasitologists, molecular biologists, and ecologists. It will provide world-class opportunities for students and researchers at Brown to engage with non-profit organizations that focus on wildlife conservation, health, and human livelihoods. PI: Tyler Kartzinel, Peggy and Henry D. Sharpe Assistant Professor of Environmental Studies, Assistant Professor of Ecology, Evolution, and Organismal Biology and the Institute at Brown for Environment and Society
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Congratulations to Elin Videvall for earning a highly competitive SRC Starting Grant to join the faculty and open her lab at Uppsala University! Elin plans to lead projects involving the microbiomes of wildlife in a changing world. Elin joined the lab with a Swedish Research Council Postdoctoral Fellowship in 2021 and we are so proud to have had a small part in her journey.
The lab is incredibly excited to welcome Mary Burak! Mary is joining the lab as a Fulbright Scholar based in Kenya followed by an IBES Voss Postdoctoral Fellowship. Together these prestigious awards will support Mary for three years both in Kenya and at Brown. Mary will collaborate with a number of major NGOs as well as scholars at the University of Nairobi, the National Museums of Kenya, and Mpala Research Centre to address critical data needs for the conservation of large carnivores and herbivores across Kenya.
Mary completed a PhD in Os Schmitz's lab at Yale University in 2023. She is a star and we are so keen to learn from her and collaborate with her over the next few years and beyond! Congratulations to Beth for having her CRISPR-based barcoding paper published at Molecular Ecology Resources! The paper is available ahead of print on the publisher's website and we will post a PDF to our lab's publications page. Our original summary based on her preprint in June is still available in the text that follows. Beth just posted a much-anticipated BioRxiv preprint describing our new efforts to repurpose CRISPR technology in ways that might help overcome persistent drawbacks to PCR and other targeted enrichment strategies in molecular ecology (doi: 10.1101/2023.06.30.547247v1). We show that we can obtain highly accurate plant DNA barcodes and assemble entire chloroplast genomes. These advances could help with species identification, discovery, and the construction of DNA reference libraries for use in a variety of applications. Moreover, we show incredible accuracy when it comes to estimating the relative abundance of DNA from a mixture of species compared to typical PCR-based methods for DNA metabarcoding.
We hope the experimental methods will be of interest and that folks working in the field will see the great potential. Once scalable, these advantages could really transform the quality and completeness of many projects that we do in the lab -- and the kinds of project we know a lot of folks are out there trying to do around the world as well! The approach was noted to be a potentially 'high risk / high reward' of the NSF CAREER award that supported our work. We'll update once it is peer-reviewed and published. Senior all-star Caroline Dressler won the 2023 Kidwell Prize! This is the top senior prize in our area of biology. Caroline was recognized for outstanding academics, a top-notch Honors thesis, consistent leadership at Brown, and a community-minded commitment to education. It was an honor to contribute to her journey -- we look forward to publishing more papers together and following her journey for years to come. Congrats, Caroline!
Congratulations to Andy Luo for a 2023 Fulbright Scholarship! On top of completing his Honors thesis and preparing to graduate, Andy can look forward to joining the amazing community of Fulbright scholars. During his program, Andy plans to teach English in Taiwan -- an amazing opportunity for a top-notch student.
Brown is typically among the top Fulbright-producing universities and Andy is the third Honors student from the lab to earn one. Amazing! Maddy Florida wins prestigious Caleel '87 Memorial Undergraduate Biology Research Fellowship3/27/2023 Congratulations to Maddy for being one of only two undergraduates to be recognized with a prestigious Caleel '87 Memorial Undergraduate Biology Research Fellowship from the Division of Biology and Medicine at Brown in 2023! To prepare for her senior thesis next year, Maddy plans to spend the summer studying the health and nutrition of sloths in Costa Rica where she'll be based at La Selva. Exciting work will come from this incredible opportunity ahead!
Beth’s scientific research is world-class. She is developing cutting-edge CRISPR-based techniques that are poised to become foundational tools in the fields of molecular ecology, food web ecology, and conservation biology. While other research wunderkinds sequester themselves, Beth has done just the opposite; she is the linchpin of the Kartzinel lab. She has expertly mentored numerous graduate and undergraduate students in the lab, but her standout achievement was in BIOL1515/2015 last Fall where she masterfully blended cutting-edge science research with creative learn-by-doing pedagogy. Beth gave those students access to authentic and impactful research experiences in the classroom that are wholly unique. I have no doubt that every undergrad from that class that goes on to a career in science will point to that semester as a pivotal experience A great way to end the summer of 2022 -- major success for two postdocs in the lab!
Colin Donihue, Voss Postdoc in IBES, accepted a full-time position as a Data Analyst at the Brown Division of Campus Life. We are so happy to know that we will get to keep seeing Colin around campus! Colin has been an amazing collaborator, lab mate, and mentor to a number of undergraduates who are completing theses and coauthoring papers. Students at Brown are lucky that he will now be applying his research creativity and skillsets toward a data-driven opportunity to improve quality of life on campus! Woohoo! Ezequiel Vanderhoeven, CONICET International Postdoc in EEOB, was awarded an Organization for Tropical Studies Early Career Fellowship! This award is an honor and a unique opportunity to join a storied community of field ecologists. Eze's project is titled "Health and nutrition of anteaters, armadillos, and sloths (Order Xenarthra)" and it will be carried out at La Selva Research Station. Fantastic opportunities lie ahead for Eze -- well deserved! |
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